Man with the Screaming Brain (2005) is an attempted send up of the B-class monster movies of old, but having seen a few of those – finally! – over the last several years, I must say I’ve been impressed by the quality of the acting and scripts in many of them – and that’s where Man with the Screaming Brain falls down. It has a lack of timing for much of the humor; gags are executed for the sake of the gag, rather than advancing the story, and this is the fault of the script. Two or three more drafts of the script were really necessary before filming should have begun.
That said, if you’re a Bruce Campbell fan, it won’t hurt you much to see this. However, his memorable Bubba Ho-Tep (2002) was a far, far better effort, and is actually worth your time. This one, despite the efforts of the actors, just doesn’t come off as much more than an amateur effort in the story.