{"id":35842,"date":"2022-05-08T17:01:42","date_gmt":"2022-05-08T22:01:42","guid":{"rendered":"http:\/\/huewhite.com\/umb\/?p=35842"},"modified":"2022-05-08T17:01:42","modified_gmt":"2022-05-08T22:01:42","slug":"a-bit-of-good-news-heaven-forbid","status":"publish","type":"post","link":"https:\/\/huewhite.com\/umb\/2022\/05\/08\/a-bit-of-good-news-heaven-forbid\/","title":{"rendered":"A Bit Of Good News? Heaven Forbid!"},"content":{"rendered":"<p><em><strong>Nature<\/strong><\/em> has an <a href=\"https:\/\/www.nature.com\/articles\/s41586-022-04599-z\" target=\"_blank\" rel=\"noopener\">article<\/a> on the <em>dissolution of plastic<\/em> &#8211; from the abstract:<\/p>\n<blockquote><p>Here, we use a structure-based, machine learning algorithm to engineer a robust and active PET hydrolase. Our mutant and scaffold combination (FAST-PETase: functional, active, stable and tolerant PETase) contains five mutations compared to wild-type PETase (N233K\/R224Q\/S121E from prediction and D186H\/R280A from scaffold) and shows superior PET-hydrolytic activity relative to both wild-type and engineered alternatives<sup><a id=\"ref-link-section-d4468025e524\" title=\"Tournier, V. et al. An engineered PET depolymerase to break down and recycle plastic bottles. Nature 580, 216\u2013219 (2020).\" href=\"https:\/\/www.nature.com\/articles\/s41586-022-04599-z#ref-CR12\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 12\">12<\/a><\/sup>\u00a0between 30 and 50\u2009\u00b0C and a range of pH levels. We demonstrate that untreated, postconsumer-PET from 51 different thermoformed products can all be almost completely degraded by FAST-PETase in 1\u2009week.<\/p><\/blockquote>\n<p>I&#8217;m not reading the actual paper, not being a PhD level chemist, but skralyx on <em><strong>Daily Kos<\/strong><\/em> <a href=\"https:\/\/www.dailykos.com\/stories\/2022\/5\/1\/2094913\/-Waste-plastic-broken-down-not-in-centuries-but-in-days-by-an-AI-engineered-enzyme?pm_source=story_sidebar&amp;pm_medium=web&amp;pm_campaign=recommended\" target=\"_blank\" rel=\"noopener\">remarks<\/a>, hopefully knowledgeably:<\/p>\n<blockquote><p>If you\u2019re concerned about the release of CO<sub>2<\/sub> by such a process, that\u2019s justified, but there\u2019s more to this story!<\/p>\n<p>Not only can this process be used to degrade PET, but in fact to reconstitute it. Once you break the polymer down into its components, you can let bacteria in the wild reduce them to CO<sub>2<\/sub> and water. OR you can re-polymerize them, which is a nifty way of casting aside any impurities like dyes or product residue and regenerating \u201cvirgin\u201d PET. This is a recycling program where you don\u2019t have to worry too much about the state of the discarded plastic.<\/p><\/blockquote>\n<p>So maybe some good news here.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature has an article on the dissolution of plastic &#8211; from the abstract: Here, we use a structure-based, machine learning algorithm to engineer a robust and active PET hydrolase. Our mutant and scaffold combination (FAST-PETase: functional, active, stable and tolerant PETase) contains five mutations compared to wild-type PETase (N233K\/R224Q\/S121E from \u2026 <a class=\"continue-reading-link\" href=\"https:\/\/huewhite.com\/umb\/2022\/05\/08\/a-bit-of-good-news-heaven-forbid\/\"> Continue reading <span class=\"meta-nav\">&rarr; <\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-35842","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/huewhite.com\/umb\/wp-json\/wp\/v2\/posts\/35842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/huewhite.com\/umb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/huewhite.com\/umb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/huewhite.com\/umb\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/huewhite.com\/umb\/wp-json\/wp\/v2\/comments?post=35842"}],"version-history":[{"count":1,"href":"https:\/\/huewhite.com\/umb\/wp-json\/wp\/v2\/posts\/35842\/revisions"}],"predecessor-version":[{"id":35843,"href":"https:\/\/huewhite.com\/umb\/wp-json\/wp\/v2\/posts\/35842\/revisions\/35843"}],"wp:attachment":[{"href":"https:\/\/huewhite.com\/umb\/wp-json\/wp\/v2\/media?parent=35842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/huewhite.com\/umb\/wp-json\/wp\/v2\/categories?post=35842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/huewhite.com\/umb\/wp-json\/wp\/v2\/tags?post=35842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}